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Reprograming of endogenous mouse alpha cells into functional beta cells, which significantly delays diabetes onset in autoimmune diabetic mice, and the successful reprograming of human alpha cells into beta cells with the same strategy represent a promising way for treating type 1 diabetes.


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In Cell Stem Cell, ... Alpha to Beta Cell Reprogramming: Stepping toward a New ... Reversal of Diabetes by the Endogenous Reprogramming of Alpha Cells into ...


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However, alpha cells may be the ideal source for beta cell replacement for several reasons. First, as endocrine cells, alpha cells are developmentally similar to beta cells, which may facilitate reprogramming (Bramswig and Kaestner, 2011; Herrera, 2000).


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Cell Stem Cell In Translation Alpha to Beta Cell Reprogramming: Stepping toward a New Treatment for Diabetes ... Endogenous reprogramming of alpha cells into


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From Xiao, Gitte &Co: Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes Successful...


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Cell Stem Cell Article Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes Xiangwei Xiao,1 ...


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Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes. / Xiao, Xiangwei; Guo, Ping; Shiota, Chiyo; Zhang, Ting; Coudriet, Gina M.; Fischbach, Shane; Prasadan, Krishna; Fusco, Joseph; Ramachandran, Sabarinathan; Witkowski, Piotr; Piganelli, Jon D.; Gittes, George K.


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CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency


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The respiratory tract contains several sources of endogenous adult stem cells residing ... alpha-1 antitrypsin ... barrier for iPS cell reprogramming.


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Gene therapy restores normal blood glucose levels in ... A study published January 4th in Cell Stem Cell ... Endogenous Reprogramming of Alpha Cells ...


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A study published January 4th in Cell Stem Cell ... "Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, ...


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A study in Cell Stem Cell demonstrates that a gene therapy approach can lead to the long-term ... "Endogenous Reprogramming of Alpha Cells into Beta ...


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You have free access to this content Brief Report: Analysis of Endogenous Oct4 Activation during Induced Pluripotent Stem Cell Reprogramming Using an ...


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In research reported last week in the journal Cell Stem Cell, ... Xiao et al.: "Endogenous Reprogramming of Alpha Cells into Beta Cells, ...


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Cell-Reprogramming Technology in Neuroscience ... from pluripotent stem cells within 3D human ... other lineages such as iPS cell reprogramming, ...


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... expanding fields of stem and progenitor cell biology. STEM CELLS welcomes original ... endogenous RNA (ceRNA) for ... Nuclear Reprogramming."


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In vivo reprogramming induces signs of cell ... the induction of endogenous telomerase by defined ... for the STEM CELLS and STEM CELLS ...


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Induced stem cells (iSC) are stem cells ... miR-34a deficiency leading to strong induction of endogenous ... fold increase in iPS cell reprogramming ...


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Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 ... Cell Line; Cellular Reprogramming*


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1. Stem Cell Res Ther. 2014;5(2):58. Role of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells.